Mr Alessandro Paluzzi

Mr. Alessandro Paluzzi is a highly experienced Consultant Neurosurgeon at University Hospitals Birmingham NHS Foundation Trust, where he practices at the Queen Elizabeth Hospital. Specialising in skull base surgery, pituitary disease, and the surgical treatment of facial pain, he has been a consultant since 2012 and is on the GMC Specialist Register.

Alex completed his medical degree at Padua University in Italy before moving to Newcastle upon Tyne for his neurosurgical training. He further enhanced his expertise with advanced fellowships in skull base surgery at Pittsburgh, USA. Additionally, he holds a Master’s degree in Surgical Technology from Imperial College London, where his work focused on innovations such as virtual reality and minimally invasive surgical techniques.

A leader in endoscopic and minimally invasive neurosurgery, Alex is internationally recognised for his work, particularly in the treatment of complex pituitary adenomas, meningiomas, and chordomas. His surgical series on endoscopic pituitary surgery is one of the most cited in the field, and his research has been published extensively in peer-reviewed journals.

Alex has been invited to lecture at major international meetings and has served as faculty on numerous skull base cadaveric courses. He is also involved in medical education and research focused on neuroplasticity and brain performance enhancement.

In addition to his NHS role, Alex offers private consultations and surgical care at HCA Harborne Hospital in Birmingham, where he maintains the same high standards of multidisciplinary care and surgical precision, with a strong emphasis on clear and compassionate communication with patients.

Courses offered

Masters Dissection Course in Endoscopic Anterior Skull Base Surgery, Walsgrage Hospital, Covetry. Faculty.

Faculty at Pituitary dissection course, Freeman hospital, Newcastle upon Tyne

Diseases, Medical Tests and Treatments


• Craniotomy for brain tumour


• Microvascular Decompression for trigeminal neuralgia and hemifacial spasm


• Percutanous glycerol injection of trigeminal ganglion


• Endoscopic endonasal approach for pituitary tumours


• Expanded endonasal approach for tumours of the skull base


• Shunt for hydrocephalus


• Endoscopic third ventriculostomy


• Trans-labyrinthine approach for acoustic neuromas


• Minimally invasive approaches for brain tumours


• Trigeminal neuralgia and facial pain


• Pituitary tumours


• Meningiomas


• Acoustic neuromas


• Gliomas


• Hemifacial spasm


• Hydrocephalus


• Idiopathic Intracranial Hypertension


• Aneurysms and vascular malformations

Publications

1: Fountas A, Lithgow K, Loughrey PB, Bonanos E, Shinwari SK, Mitchell K,

Mavilakandy A, Ahsan M, Matheou M, Isand K, Hamblin R, McLaren DS, Ullah HZ,

Grixti L, MacFarlane J, Jayasuriya A, Bhatti S, Wunna W, Shah S, Hussein Z,

Mathew S, Klaucane K, Ayuk J, Toogood A, Tsermoulas G, Ahmed S, Paluzzi A, Batra

R, Vamvakopoulos J, Krishnan A, Higham C, Abraham P, Baldeweg SE, Purewal T,

Panicker J, Martin N, Drake WM, Ahluwalia R, Newell-Price J, Gurnell M, Mamoojee

Y, Brooke A, Lansdown A, Murray RD, Bradley K, Pal A, Reddy N, Levy MJ, Freel

EM, Jose B, Hunter SJ, Karavitaki N. Conservatively managed non-functioning

pituitary macroadenomas - cohort study from the UK Non-functioning Pituitary

Adenoma Consortium. Eur J Endocrinol. 2025 Apr 30:lvaf091. doi:

10.1093/ejendo/lvaf091. Epub ahead of print. PMID: 40305776.

2: Goel A, Kulkarni G, Cotici A, Paluzzi A, Hayton T, Chelvarajah R. Volume

maximised glycerol rhizolysis for trigeminal neuralgia: a single centre analysis

of outcomes. Br J Neurosurg. 2025 Apr;39(2):191-196. doi:

10.1080/02688697.2023.2207657. Epub 2023 May 5. PMID: 37144252.

3: CRANIAL Consortium. Machine learning driven prediction of cerebrospinal fluid

rhinorrhoea following endonasal skull base surgery: A multicentre prospective

observational study. Front Oncol. 2023 Mar 23;13:1046519. doi:

10.3389/fonc.2023.1046519. PMID: 37035179; PMCID: PMC10076706.

4: Land T, Silva D, Paluzzi A, Tsermoulas G, Ahmed S. Endonasal skull base

repair with a vascularised pedicled temporo-parietal myo-fascial flap.

Laryngoscope Investig Otolaryngol. 2022 Dec 30;8(1):55-62. doi:

10.1002/lio2.1000. PMID: 36846405; PMCID: PMC9948560.

5: CRANIAL Consortium. CSF rhinorrhoea after endonasal intervention to the skull

base (CRANIAL): A multicentre prospective observational study. Front Oncol. 2023

Jan 4;12:1049627. doi: 10.3389/fonc.2022.1049627. PMID: 36688936; PMCID:

PMC9846732.

6: Lee JDE, Richards E, Mawji S, Paluzzi A, Tsermoulas G, Ahmed S. The 'muscle

wonton' repair - A case series of internal carotid artery injuries at a single

Centre during its 10-year experience in endoscopic transsphenoidal pituitary

surgery. Br J Neurosurg. 2024 Aug;38(4):934-938. doi:

10.1080/02688697.2021.2011138. Epub 2022 May 13. PMID: 35549579.

7: Metcalfe C, Muzaffar J, Kulendra K, Sanghera P, Shaw S, Shad A, Saravanappa

N, Paluzzi A, Ahmed S. Chordomas and chondrosarcomas of the skull base:

treatment and outcome analysis in a consecutive case series of 24 patients.

World J Surg Oncol. 2021 Mar 9;19(1):68. doi: 10.1186/s12957-021-02178-6. PMID:

33750413; PMCID: PMC7945343.

8: Kawsar KA, Land T, Tsermoulas G, Paluzzi A, Ahmed S. Novel Surgical Treatment

of Recurrent CSF Leak by Temporoparietal Temporalis Myofascial Flap: A Series of

6 Cases. World Neurosurg. 2021 Mar;147:1-6. doi: 10.1016/j.wneu.2020.11.156.

Epub 2020 Dec 5. PMID: 33290899.

9: Abussuud Z, Ahmed S, Paluzzi A. Surgical Approaches to the Orbit: A

Neurosurgical Perspective. J Neurol Surg B Skull Base. 2020 Aug;81(4):385-408.

doi: 10.1055/s-0040-1713941. Epub 2020 Sep 9. PMID: 33209566; PMCID: PMC7661317.

10: Yousaf J, Afshari FT, Ahmed SK, Chavda SV, Sanghera P, Paluzzi A. Endoscopic

endonasal surgery for Clival Chordomas - a single institution experience and

short term outcomes. Br J Neurosurg. 2019 Aug;33(4):388-393. doi:

10.1080/02688697.2019.1567683. Epub 2019 Feb 11. PMID: 30741028.

11: Tampourlou M, Ntali G, Ahmed S, Arlt W, Ayuk J, Byrne JV, Chavda S, Cudlip

S, Gittoes N, Grossman A, Mitchell R, O'Reilly MW, Paluzzi A, Toogood A, Wass

JAH, Karavitaki N. Outcome of Nonfunctioning Pituitary Adenomas That Regrow

After Primary Treatment: A Study From Two Large UK Centers. J Clin Endocrinol

Metab. 2017 Jun 1;102(6):1889-1897. doi: 10.1210/jc.2016-4061. PMID: 28323946.

12: Lavrentaki A, Paluzzi A, Wass JA, Karavitaki N. Epidemiology of acromegaly:

review of population studies. Pituitary. 2017 Feb;20(1):4-9. doi:

10.1007/s11102-016-0754-x. PMID: 27743174; PMCID: PMC5334410.

13: Tampourlou M, Trifanescu R, Paluzzi A, Ahmed SK, Karavitaki N. THERAPY OF

ENDOCRINE DISEASE: Surgery in microprolactinomas: effectiveness and risks based

on contemporary literature. Eur J Endocrinol. 2016 Sep;175(3):R89-96. doi:

10.1530/EJE-16-0087. Epub 2016 May 20. PMID: 27207245.

14: Bajwa R, Kaur PP, Paluzzi A. Headaches and hormones: a potentially lethal

combination. BMJ. 2016 Jan 26;352:h6752. doi: 10.1136/bmj.h6752. PMID: 26812964.

15: Capatina C, Paluzzi A, Mitchell R, Karavitaki N. Diabetes Insipidus after

Traumatic Brain Injury. J Clin Med. 2015 Jul 13;4(7):1448-62. doi:

10.3390/jcm4071448. PMID: 26239685; PMCID: PMC4519799.

16: Paluzzi A, Gardner PA, Fernandez-Miranda JC, Tormenti MJ, Stefko ST,

Snyderman CH, Maroon JC. "Round-the-Clock" Surgical Access to the Orbit. J

Neurol Surg B Skull Base. 2015 Feb;76(1):12-24. doi: 10.1055/s-0033-1360580.

Epub 2014 Sep 2. PMID: 25685644; PMCID: PMC4318736.

17: Vaezi A, Cardenas E, Pinheiro-Neto C, Paluzzi A, Branstetter BF 4th, Gardner

PA, Snyderman CH, Fernandez-Miranda JC. Classification of sphenoid sinus

pneumatization: relevance for endoscopic skull base surgery. Laryngoscope. 2015

Mar;125(3):577-81. doi: 10.1002/lary.24989. Epub 2014 Nov 24. PMID: 25417777.

18: Gande A, Tormenti MJ, Koutourousiou M, Paluzzi A, Fernendez-Miranda JC,

Snydermnan CH, Gardner PA. Intraoperative computed tomography guidance to

confirm decompression following endoscopic endonasal approach for

cervicomedullary compression. J Neurol Surg B Skull Base. 2013 Feb;74(1):44-9.

doi: 10.1055/s-0032-1329627. Epub 2013 Jan 2. PMID: 24436887; PMCID: PMC3699170.

19: Koutourousiou M, Gardner PA, Stefko ST, Paluzzi A, Fernandez-Miranda JC,

Snyderman CH, Maroon JC. Combined endoscopic endonasal transorbital approach

with transconjunctival-medial orbitotomy for excisional biopsy of the optic

nerve: technical note. J Neurol Surg Rep. 2012 Oct;73(1):52-6. doi:

10.1055/s-0032-1323156. Epub 2012 Aug 18. PMID: 23946927; PMCID: PMC3658658.

20: Paluzzi A, Fernandez-Miranda JC, Tonya Stefko S, Challinor S, Snyderman CH,

Gardner PA. Endoscopic endonasal approach for pituitary adenomas: a series of

555 patients. Pituitary. 2014 Aug;17(4):307-19. doi: 10.1007/s11102-013-0502-4.

PMID: 23907570.

21: Pinheiro-Neto CD, Paluzzi A, Fernandez-Miranda JC, Scopel TF, Wang EW,

Gardner PA, Snyderman CH. Extended dissection of the septal flap pedicle for

ipsilateral endoscopic transpterygoid approaches. Laryngoscope. 2014

Feb;124(2):391-6. doi: 10.1002/lary.24256. Epub 2013 Oct 22. PMID: 23775318.

22: Koutourousiou M, Gardner PA, Fernandez-Miranda JC, Paluzzi A, Wang EW,

Snyderman CH. Endoscopic endonasal surgery for giant pituitary adenomas:

advantages and limitations. J Neurosurg. 2013 Mar;118(3):621-31. doi:

10.3171/2012.11.JNS121190. Epub 2013 Jan 4. PMID: 23289816.

23: Shin SS, Tormenti MJ, Paluzzi A, Rothfus WE, Chang YF, Zainah H, Fernandez-

Miranda JC, Snyderman CH, Challinor SM, Gardner PA. Endoscopic endonasal

approach for growth hormone secreting pituitary adenomas: outcomes in 53

patients using 2010 consensus criteria for remission. Pituitary. 2013

Dec;16(4):435-44. doi: 10.1007/s11102-012-0440-6. PMID: 23179961.

24: Paluzzi A, Fernandez-Miranda J, Torrenti M, Gardner P. Retracing the

etymology of terms in neuroanatomy. Clin Anat. 2012 Nov;25(8):1005-14. doi:

10.1002/ca.22053. Epub 2012 Mar 30. PMID: 23112209.

25: Mukerji N, Paluzzi A, Crossman J, Mitchell P, Nissen J. Emergency

neurosurgical referrals in the North East of England - trends over four years

2008-2011. Br J Neurosurg. 2013 Jun;27(3):334-9. doi:

10.3109/02688697.2012.717979. Epub 2012 Sep 5. PMID: 22950542.

26: Paluzzi A, Gardner P, Fernandez-Miranda JC, Snyderman C. The expanding role

of endoscopic skull base surgery. Br J Neurosurg. 2012 Oct;26(5):649-61. doi:

10.3109/02688697.2012.673649. Epub 2012 Apr 3. PMID: 22471243.

27: Paluzzi A, Fernandez-Miranda JC, Pinheiro-Neto C, Alcocer-Barradas V, Lopez-

Alvarez B, Gardner P, Snyderman C. Endoscopic endonasal infrasellar approach to

the sellar and suprasellar regions: technical note. Skull Base. 2011

Sep;21(5):335-42. doi: 10.1055/s-0031-1280682. PMID: 22451835; PMCID:

PMC3312132.

28: Scopel TF, Fernandez-Miranda JC, Pinheiro-Neto CD, Peris-Celda M, Paluzzi A,

Gardner PA, Hirsch BE, Snyderman CH. Petrous apex cholesterol granulomas:

endonasal versus infracochlear approach. Laryngoscope. 2012 Apr;122(4):751-61.

doi: 10.1002/lary.22448. PMID: 22434679.

29: Tormenti MJ, Paluzzi A, Pinheiro-Nieto C, Fernandez-Miranda JC, Snyderman

CH, Gardner PA. Endoscopic endonasal repair of spontaneous CSF fistulae. J

Neurosurg. 2012 Jan;32 Suppl:E6. PMID: 22251254.

30: Paluzzi A, Gardner P, Fernandez-Miranda JC, Pinheiro-Neto CD, Scopel TF,

Koutourousiou M, Snyderman CH. Endoscopic endonasal approach to cholesterol

granulomas of the petrous apex: a series of 17 patients: clinical article. J

Neurosurg. 2012 Apr;116(4):792-8. doi: 10.3171/2011.11.JNS111077. Epub 2012 Jan

6. PMID: 22224788.

31: Tormenti MJ, Paluzzi A, Pinheiro-Neto CD, Fernandez-Miranda JC, Snyderman

CH, Gardner PA. Endoscopic endonasal repair of spontaneous CSF fistulae.

Neurosurg Focus. 2012 Jan;32 Suppl 1:E6. doi: 10.3171/2012.V6.FOCUS11304. PMID:

26018976.

32: Pinheiro-Neto CD, Fernandez-Miranda JC, Rivera-Serrano CM, Paluzzi A,

Snyderman CH, Gardner PA, Sennes LU. Endoscopic anatomy of the palatovaginal

canal (palatosphenoidal canal): a landmark for dissection of the vidian nerve

during endonasal transpterygoid approaches. Laryngoscope. 2012 Jan;122(1):6-12.

doi: 10.1002/lary.21808. Epub 2011 Nov 15. PMID: 22086784.

33: Mukerji N, Cahill J, Paluzzi A, Holliman D, Dambatta S, Kane PJ. Emergency

head CT scans: can neurosurgical registrars be relied upon to interpret them? Br

J Neurosurg. 2009 Apr;23(2):158-61. doi: 10.1080/02688690902730723. PMID:

19306170.

34: Paluzzi A, Viva LJ, Kalsi P, Mukerji N, Tzerakis N, Patton MA. Ruptured

cerebral aneurysm in a patient with Floating-Harbor syndrome. Clin Dysmorphol.

2008 Oct;17(4):283-5. doi: 10.1097/MCD.0b013e328306a38d. PMID: 18978661.

35: Padovani D, Aimoni C, Zucchetta P, Paluzzi A, Pastore A. 18-FDG PET in the

diagnosis of laterocervical metastases from occult carcinoma. Eur Arch

Otorhinolaryngol. 2009 Feb;266(2):267-71. doi: 10.1007/s00405-008-0733-6. Epub

2008 Jun 28. PMID: 18587594.

36: Paluzzi A, Belli A, Bain P, Viva L. Brain 'imaging' in the Renaissance. J R

Soc Med. 2007 Dec;100(12):540-3. doi: 10.1177/014107680710001209. PMID:

18065703; PMCID: PMC2121627.

37: Paluzzi A, Bain PG, Liu X, Yianni J, Kumarendran K, Aziz TZ. Pregnancy in

dystonic women with in situ deep brain stimulators. Mov Disord. 2006

May;21(5):695-8. doi: 10.1002/mds.20777. PMID: 16281297.