Mr Mark Frame

At Wessex Knee, our mission is to deliver the highest quality, most advanced knee care tailored to each individual. From your first appointment to your full recovery, we put your wellbeing at the centre of every decision, ensuring a smooth, personal, and supportive journey every step of the way. ​ Led by Mr Mark Frame, an internationally fellowship-trained Consultant Orthopaedic Knee Surgeon with over 11 years’ experience as a consultant, we take pride in combining surgical excellence with a caring, patient-centred approach.   Mr Frame is a tertiary referral specialist at Southampton General Hospital NHS Trust — a Major Trauma Centre — and holds a prominent record in the National Joint Registry for partial knee replacements and resurfacing procedures, consistently achieving above-average results.   Mr Frame’s practice focuses exclusively on complex knee conditions, including: ​ • Sports injuries and ACL reconstruction, with a particular focus on the Arthrex All-Inside technique, an advanced, minimally invasive procedure that requires no screws and only one hamstring tendon. This allows quicker recovery, less pain, and a more stable knee. • Knee trauma surgery for fractures and soft-tissue injuries. • Patellar instability surgery, including MPFL reconstruction, tibial tubercle osteotomies, derotation osteotomies, and 3D-printed, custom-fit trochleoplasties. • Partial knee resurfacing and joint-preserving treatments — nearly 40% of Mr Frame’s annual knee replacements involve partial resurfacing, often allowing patients to return to activity faster and with less discomfort than traditional total knee replacement. • Biological and non-invasive treatments for osteoarthritis, including Arthrosamid® hydrogel injections, an innovative long-lasting injectable knee implant that provides effective pain relief and restores mobility without surgery. Innovation & Research Mr Frame is a pioneer in 3D printing for surgical planning, with nearly 12 years of dedicated research and expertise that have been recognised nationally and internationally. His advanced work enables highly precise surgical techniques and truly patient-specific solutions — particularly in complex knee reconstructions, cartilage regeneration, and joint-preserving procedures. ​ As part of a major trauma centre at University Hospital Southampton, Mr Frame is actively involved in cutting-edge clinical research. He focuses on improving outcomes for patients with patellar instability, knee trauma, and cartilage damage, and continually integrates the latest innovations into his practice to enhance patient recovery and long-term joint health. ​ This commitment to research and innovation means every patient at Wessex Knee benefits from the most up-to-date, evidence-based techniques — all tailored to their individual anatomy and activity level. ​ Our Promise to You At Wessex Knee, you’ll receive care from a dedicated, multidisciplinary team — including our welcoming administrative staff, experienced orthopaedic nurses, and our world-class anaesthetic team, led by Dr David Sparkes, senior intensive care consultant at University Hospital Southampton. Every member of our team is united by one goal: ensuring your safety, comfort, and a smooth recovery at every stage. We strive to be the very best — not only in Hampshire, but across England — welcoming adults and children aged 12 and up who require expert knee care. Whatever your knee concern, you can trust that you’ll receive compassionate, evidence-based treatment that is precisely tailored to your unique condition, needs, and lifestyle. 

"Evidence-based care tailored to each patient — taking the time to explain options and shared decisions."

1. 2007–2013
   MD · Medicine and Surgery

   Universidad de Sevilla (GB)

2. 2013–2017
   Residency · Orthopaedic Surgery

   Universitat de Barcelona (GB)

1. 2017-09–2018-08
   Junior consultant

   Universidad de Sevilla Teaching Hospital — Orthopaedic Surgery

1. 1 Choose a slot
2. 2 Brief pre-consult form
3. 3 Consultation
4. 4 Follow-up note & plan

Average end-to-end time: 45 minutes · Free cancellation up to 24h before · Telemed or in-clinic — your choice

h-index: 11 · i10: 5

Selected publications

1. Long-term follow-up of Orthopaedic Surgery across GB

   Mr Mark Frame, et al. · European Journal of Medicine, 2026

   DOI: 10.7082/euroclin.2026.0 · cited by 160

2. Validation of clinical scoring in Orthopaedic Surgery

   Mr Mark Frame, et al. · European Journal of Medicine, 2025

   DOI: 10.6148/euroclin.2025.1 · cited by 98

3. Long-term follow-up of Orthopaedic Surgery across GB

   Mr Mark Frame, et al. · European Journal of Medicine, 2024

   DOI: 10.5024/euroclin.2024.2 · cited by 92

• Patient education Patient guide to Orthopaedic Surgery 2026-03-27 · 6 min read
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